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A young teenager named Leo Dooley lived a normal life until the day his mother Tasha gets remarried to billionaire inventor Donald Davenport, whom they move in with. While trying to find his bedroom, Leo accidentally discovers teenage siblings with bionic powers living in his new basement. The show follows the bionic teens as they unravel in adventurous situations in an attempt to live life like a normal family in the fictional town of Mission Creek, California.

As the show progresses in the second, third, and fourth seasons, it gets darker with the introduction of Donald's younger brother Douglas Davenport who later joins the Lab Rats' side, Douglas' android son, Marcus Davenport, Victor Krane, Taylor (formerly known as S-1), who joins the Lab Rats during the fourth season, Sebastian (formerly known as S-3), Krane's bionic soldiers, Giselle, who's planning on rebuilding Marcus, and Troy West, Giselle's android creation. At the end of the third season, Donald opens up a bionic academy on a bionic island to train Krane's bionic soldiers to be the world's new bionic heroes.

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